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KMID : 1007320080140010017
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Journal of the Korean Society of Menopause
2008 Volume.14 No. 1 p.17 ~ p.26
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The Effects of Combined Low Dose Estrogen and Fluocalcic Effervescent Therapy on the Bone Mineral Density and Bone Metabolism in Menopausal Women with Osteopenia
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Kang Ae-Ra
Kim Heung-Yeol
Eo Wan-Kyu
Oh Young-Rim
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Abstract
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Objectives: To evaluate the effects of combined estrogen and fluocalcic therapy on the bone metabolism in the surgicalyl menopausal womenwith osteopenia.
Methods: This prospective randomized clinical trial examined the effects of conjugated equine estrogen and fluocalcic in combination and separately, on BMD in 200 women with low bone mass. Treatment included 0.3 mg conjugated equine estrogen (CEE) (Group I), 0.625 mg CEE (Group II), 0.3 mg CEE plus fluocalcic (Group III), and 0.625 mg CEE plus fluocalcic (Group IV) for 12 months. Biochemical markers of bone turnover were also measured every six months.
Results: BMD of lumbar spine (L2∼4) increased significantly during the treatment in Group III and Group IV (P＜0.05). Urinary deoxypyridinoline in Group III and Group IV decreased signifiantly at 12 months of treatment (P＜0.005). Serum osteocalcin and total alkaline phosphatase decreased slightly during the treatment in all groups but statistical significance was not found.
Conclusion: The combined treatment with low or standard dose CEE plus fluocalcic is more effective in surgically menopausal women with osteopenia by increasing BMD and decreasing bone biochemical marker than CEE only group.
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KEYWORD
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Osteopenia, Conjugated equine estrogen, Fluocalcic
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